
The global aesthetic market has proliferated, with non-invasive treatments like injectable skin boosters leading the way. These treatments are famous for their convenience and quick results, making them a top choice for skin rejuvenation.
Nucleofill and Rejuran are standout options in this category. While both aim to improve skin health, they differ in approach—Nucleofill deeply hydrates and stimulates collagen with polynucleotides, while Rejuran uses salmon DNA to repair and renew the skin. Each is suited to different skincare goals.
In this article, we’ll break down the benefits, differences, and best uses of Nucleofill vs Rejuran to help you decide which treatment is right for you.
Key Takeaways
- Nucleofill and Rejuran are popular aesthetic treatments for skin rejuvenation and anti-aging purposes.
- Nucleofill and Rejuran have different active ingredients and mechanisms of action, leading to varying intended applications and effectiveness.
- Understanding the strengths and weaknesses of each treatment is crucial for practitioners and patients to make informed decisions.
About: Doctor Medica is your trusted supplier of top-quality dermal fillers, viscosupplements, and more for your medical practice. We offer genuine products from leading brands at the lowest prices in the market. If you’re looking to order Nucleofill online for your practice, contact the Doctor Medica today.
Understanding Nucleofill and Rejuran

Nucleofill and Rejuran are two popular treatments for boosting skin, but they work in different ways.
Nucleofill uses polynucleotides to deeply hydrate the skin, promote collagen production, and improve elasticity. This makes it especially helpful for reducing pore size, smoothing texture, and adding moisture, giving skin a more youthful glow. For the best results, most people see benefits after two to four sessions, leaving skin plump and refreshed.
Rejuran takes a different approach, using salmon DNA to repair and rejuvenate the skin. Known for its compatibility with all skin types and low risk, Rejuran helps restore skin health by promoting collagen and elastin, which are essential for firmness and resilience. Typically, three to four sessions are recommended to see the full effects, which include firmer, smoother skin that looks naturally revitalized.
Active Ingredients and Mechanisms of Action

Nucleofill works primarily with polynucleotides, DNA fragments that naturally support skin repair. When injected, these polynucleotides boost hydration by drawing in moisture and enhancing the skin’s natural barrier. They also act as biostimulants, encouraging skin cells to produce more collagen and elastin, helping the skin become firmer, smoother, and more resilient.
Meanwhile, Rejuran relies on a rich source of salmon DNA. Known for its compatibility with human skin, salmon DNA works on a cellular level to repair and restore. By supporting cellular turnover, Rejuran aids in collagen production and improves skin structure, making the skin appear firmer and healthier. This targeted DNA repair helps address issues like fine lines and uneven skin tone, offering a gradual but noticeable improvement.
Intended Applications and Effectiveness

Nucleofill is designed to deliver deep hydration and stimulate collagen production, which can improve overall skin quality. It’s particularly effective for enhancing skin texture, tightening pores, and providing a gentle lifting effect. To get the best results, precise Nucleofill injection points are used to target areas that need hydration and elasticity, with most people seeing optimal outcomes after two to four sessions.
As for Rejuran, it focuses specifically on anti-aging through skin repair. With salmon DNA as its active ingredient, Rejuran supports cellular turnover and restores youthful vitality to the skin. Generally, three to four sessions are recommended to achieve visible results, with each treatment helping to smooth fine lines, firm the skin, and create a refreshed appearance.
Strengths and Weaknesses
Nucleofill is excellent for deep hydration and skin improvement, making it a top choice for those looking to smooth skin texture, tighten pores, and boost elasticity. Its collagen-stimulating effects add subtle lift and firmness, especially when targeting areas that need a hydration boost. However, the results from Nucleofill aren’t instant—it usually takes a few sessions to see the full benefits, which might not suit anyone looking for immediate results.
Thanks to the salmon DNA it contains, Rejuran stands out for its anti-aging and skin-repair benefits. It’s particularly effective for softening fine lines and giving the skin a fresh, youthful look through cellular renewal. Like Nucleofill, Rejuran’s effects build gradually over several treatments. Additionally, those with sensitivities to salmon-based products should consider this carefully before opting for Rejuran.
Conclusion
Nucleofill and Rejuran both work wonders for the skin, but they use different ingredients to achieve their results. Nucleofill is great for deep hydration and boosting skin quality, making it ideal for anyone looking for added moisture and a subtle lift with fewer sessions.
Rejuran is packed with salmon DNA, which focuses on repairing and refreshing the skin, especially if you want to soften fine lines and improve texture. Both treatments are safe for all skin types and help boost collagen, so the choice depends on what your skin needs most and how many sessions you’re ready for.
FAQs
1. What is Nucleofill and Rejuran?
Nucleofill and Rejuran are treatments used in aesthetic medicine. Nucleofill focuses on skin rejuvenation, while Rejuran is known for its healing properties.
2. How do Nucleofill and Rejuran treatments work?
Both treatments involve injecting substances into the skin. Nucleofill is a compound rich in nucleotides, which stimulate cell regeneration. On the other hand, Rejuran uses polynucleotides from salmon DNA to promote healing.
3. Are there any side effects with these treatments?
Like all medical procedures, both can have side effects. Common ones include redness or swelling at injection sites. However, these usually go away quickly.
4. Which treatment is better – Nucleofill or Rejuran?
It depends on your needs! If you’re looking for skin rejuvenation, consider Nucleofill. But if you need faster healing after an aesthetic procedure, then perhaps Rejuran would be more suitable.
References
Non-invasive Aesthetic Treatment Market Size, 2030. Grand View Research. https://www.grandviewresearch.com/industry-analysis/non-invasive-aesthetic-treatment-market
Nucleofill. (n.d.). Retrieved October 24, 2024, from https://www.nucleofill.fr/en/
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