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AZZALURE®

AZZALURE® is a European botulinum neurotoxin type-A product, a muscle relaxant licensed exclusively for aesthetic use. It is sold in powder form to be dissolved into solutions for injections. 

Let’s look at everything you need to know about this treatment and find out where you can buy AZZALURE® online.

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What Is AZZALURE® Used For?

AZZALURE® is a muscle relaxant that contains botulinum toxin A. It is used for improving the appearance of moderate to severe glabellar lines (vertical frown lines between the eyebrows) and lateral canthal lines (crow’s feet lines).    AZZALURE® acts at the junction between the nerves and muscles to prevent the release of a chemical messenger called acetylcholine. This prevents muscles from contracting, reducing the appearance of skin tension lines. The muscle relaxation is temporary and gradually wears off.

When Should AZZALURE® Not Be Used?

AZZALURE® should not be administered to individuals who: 
  • Are allergic to clostridium botulinum toxin A or any of the other ingredients of the formulation 
  • Have an infection at the proposed site of injection 
  • Have myasthenia gravis, Eaton-Lambert Syndrome, or amyotrophic lateral sclerosis
  • Are pregnant or breastfeeding 
  • Have dysphagia (difficulty swallowing food) 
  • Have weak muscles at the proposed site of injection 
  • Suffer from a bleeding disorder such as hemophilia
  • Have had surgery on their face or are likely to undergo facial surgery soon
  • Have already had other botulinum toxin injections 
  • Have seen no significant improvement in facial lines after previous treatment with botulinum toxin
It should also not be administered to individuals under 18 or over 65 years of age. 

AZZALURE® Administration Technique

AZZALURE® should be administered only by a licensed medical professional with the appropriate qualifications and expertise in this treatment.  Here are some guidelines for administering AZZALURE®. 

Glabellar Lines 

The injections should be administered intramuscularly, at right angles to the skin, into each of the five sites.  You give two injections into each corrugator muscle and one into the procerus muscle near the nasofrontal angle.  Before injection, place the thumb or index finger firmly below the orbital rim in order to prevent extravasation into the area. The needle should be pointed upward and medially during the injection. In order to reduce the risk of ptosis, avoid injections near the levator palpebrae superioris muscle, particularly in patients with depressor supercilii.  Also, injections in the corrugator muscle must be made into the central part of the muscle, at least one cm above the orbital rim.

Lateral Canthal lines

For lateral canthal lines, ten Speywood units are to be administered intramuscularly into each injection point. The injection should be lateral (20 - 30° angle) to the skin and very superficial. In addition, all injection points should be at the external part of the orbicularis oculi muscle and sufficiently far from the orbital rim (approximately one to two centimeters).  Observing and palpating the anatomical landmarks at the maximal smile can help you more easily identify them. Also, take care to avoid injecting the zygomaticus major/minor muscles to prevent lateral mouth drop and asymmetrical smile.

Recommended Dosage

The recommended dosage of AZZALURE® is: 
  • For glabellar lines – 50 units, injected as ten units each at the five injection sites in the forehead.
  • For lateral canthal lines – 60 units, injected as ten units at each of the six injection sites in both crow’s feet regions.
The effect of the treatment is noticeable within a few days after the injection. The interval between treatments should be determined by the healthcare practitioner but it should not be administered more often than once every 12 weeks. 

AZZALURE® Side Effects

AZZALURE® side effects are usually mild and disappear within the first week of treatment.  Some common side effects include: 
  • Redness, swelling, irritation, rash, itching, tingling, pain, discomfort, stinging, or bruising at the injection site (one in ten users)
  • Headache (one in ten users)
  • Tired eyes or dim vision, drooping of the upper eyelid, swelling of the eyelid, watering eyes, dry eye, twitching of muscles around the eye, or temporary facial paralysis (one to ten in 100 users) 
Severe side effects include: 
  • Disturbed, blurred, or double vision, dizziness, itching, rashes, allergic reactions (one to ten in 1,000 users)
  • Itchy and lumpy rashes and eye movement disorder (one to ten in 10,000 users)

AZZALURE® vs. The Competition

Botox is AZZALURE®’s main competition in the market. Both products are FDA-approved and have similar results.  One main difference is that Botox has a larger molecular structure than AZZALURE®, meaning it does not diffuse into tissues as quickly. This means that patients may require more injection points with Botox than with AZZALURE®.  Another difference is that Botox is used to treat a range of other health-related issues, including chronic migraines, severe underarm sweating, and issues involving overactive bladders. However, AZZALURE® has been approved only as a cosmetic injection. 

Where Can I Buy AZZALURE®?

AZZALURE® is made by the French company Ipsen and marketed in the UK by Galderma. It is typically sold in powder form, with a pack size of one or two vials.  If you’re looking to order AZZALURE® online, feel free to reach out to our experts at Doctor Medica. We can help you buy AZZALURE® wholesale safely.

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