XEOMIN® 100u

XEOMIN® 100u (incobotulinumtoxinA) is a purified botulinum neurotoxin type A preparation used for intramuscular injection. It works by temporarily blocking the release of acetylcholine at neuromuscular junctions, resulting in muscle relaxation or reduced muscle activity. Unlike other botulinum products, XEOMIN is free of complexing proteins, potentially reducing the risk of antibody formation and loss of efficacy over time.

• Approved since: 2010 (U.S. FDA)

• Formulation: Lyophilized powder for reconstitution

• Indications: Glabellar lines, cervical dystonia, blepharospasm, and upper limb spasticity

• Manufacturer: Merz Pharmaceuticals

XEOMIN® is administered by intramuscular injection only, and treatment protocols vary based on the indication and patient history. Dosing is not interchangeable with other botulinum toxin products.

Key Features:

• Single-patient use; reconstituted solution must be used within 24 hours

• Re-treatment intervals should be no sooner than every 12 weeks

Example Dosage by Indication:

• Glabellar Lines: 20 Units (4 U x 5 sites)

• Cervical Dystonia: Starting dose of 120 Units

• Blepharospasm: 1.25–2.5 Units per site, max 70 U total

• Upper Limb Spasticity: Up to 400 Units total per session

Needle Guidelines:

• Use 30–33G for superficial facial areas

• Use 22–26G for deeper or larger muscles

XEOMIN® is indicated for several therapeutic and aesthetic uses in adult patients. It is contraindicated in patients with allergies to botulinum toxins or injection site infections. Common adverse effects are dose and site dependent.

Approved Indications:

• Upper limb spasticity

• Cervical dystonia

• Blepharospasm (previously treated with onabotulinumtoxinA)

• Moderate-to-severe glabellar lines

Contraindications:

• Known hypersensitivity to botulinum toxin A or excipients

• Active infection at injection site

Common Side Effects:

• Glabellar lines: Headache (5.4%), facial paresis

• Blepharospasm: Eyelid ptosis (19%), dry mouth, dry eye

• Cervical dystonia: Dysphagia (13–18%), neck pain, muscle weakness

• Upper limb spasticity: Seizure (3%), dry mouth

Each vial of XEOMIN® 100u contains 100 Units of incobotulinumtoxinA, with no accessory proteins.

Ingredients per 100u vial:

• Active: IncobotulinumtoxinA – 100 Units

• Excipients:

  • Human albumin – 1 mg

  • Sucrose – 4.7 mg

This formulation does not contain preservatives and must be reconstituted with preservative-free 0.9% Sodium Chloride.

Each XEOMIN® 100u package contains a single-dose vial with lyophilized powder intended for reconstitution.

Package Contents:

• 1 glass vial containing 100 Units of XEOMIN (powder form)

• Tamper-proof aluminum seal

• Latex-free rubber stopper

• No diluent included

Yes, XEOMIN may cause localized and systemic side effects, which vary by treatment area and patient sensitivity. Side effects may occur hours to weeks after injection.

Common Adverse Events:

• Injection site pain, hematoma

• Headache, eyelid ptosis, dry mouth, visual disturbances

• Respiratory issues in sensitive patients

• Severe risks: Dysphagia, dyspnea, spread of toxin effect

Note: Risk of systemic effects is increased in patients with neuromuscular conditions or when injected near critical structures.

XEOMIN® 100u must be stored under controlled conditions to maintain potency and safety. Once reconstituted, it has a 24-hour usage window.

Storage Instructions:

• Unopened vial:

  • Store at room temperature (20–25°C), refrigerator (2–8°C), or freezer (–20 to –10°C)

• Reconstituted vial:

  • Store in refrigerator at 2–8°C

  • Use within 24 hours

  • Discard any unused product after this period